Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564929 | 0.82 | PIK3CD (0.51) | ERBB2HRH3 | |
| SCHEMBL5566186 | 0.81 | HRH3 (0.49) | CHRM4HRH3EGFR | |
| SCHEMBL14489819 | 0.80 | EGFR (0.49) | CHRM4ERBB2EGFR | |
| SCHEMBL6017316 | 0.79 | ENPP1 (0.52) | PDE3BPDE3APDE10AERBB2EGFR | |
| SCHEMBL5754733 | 0.79 | ENPP1 (0.52) | PDE3BPDE3APDE10AERBB2EGFR | |
| SCHEMBL1527983 | 0.79 | EGFR (0.47) | CHRM4ERBB2EGFR | |
| SCHEMBL14489815 | 0.78 | GPR119 (0.47) | CHRM4ERBB2EGFR | |
| Hydrochloric Acid SCHEMBL4967454 | 0.78 | EGFR (0.46) | CHRM4ERBB2EGFR | |
| SCHEMBL5568756 | 0.77 | ERBB2 (0.47) | CHRM4ERBB2EGFR | |
| SCHEMBL5569914 | 0.77 | EGFR (0.53) | PDE3BPDE3APDE10AERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664028-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026151-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |