Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617384 | 0.84 | PPARD (0.45) | TRPV1PPARAPPARGPPARDKDM4E | |
| SCHEMBL5669972 | 0.79 | PPARD (0.41) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6052634 | 0.78 | PPARD (0.52) | PPARAPPARGPPARD | |
| SCHEMBL6029170 | 0.77 | MCL1 (0.41) | PPARAPPARGPPARD | |
| SCHEMBL6030489 | 0.77 | PPARD (0.48) | PPARAPPARGPPARD | |
| SCHEMBL6052594 | 0.77 | PPARA (0.44) | PPARAPPARGPPARD | |
| SCHEMBL5617387 | 0.77 | PPARD (0.49) | PPARAPPARGPPARDNR1H2NR1H3 | |
| SCHEMBL6017372 | 0.76 | PKM (0.43) | TRPV1PPARAPPARGPPARD | |
| SCHEMBL6052586 | 0.76 | PPARD (0.51) | PPARAPPARGPPARD | |
| SCHEMBL6218546 | 0.76 | PPARD (0.59) | PPARAPPARGPPARDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |