Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | TDO2 | P48775 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29264091 | 0.79 | TDO2 (0.60) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3045915 | 0.79 | IDO1 (0.54) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26984226 | 0.77 | IDO1 (0.51) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21290347 | 0.76 | IDO1 (0.54) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3318438 | 0.76 | NPC1 (0.69) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3318446 | 0.75 | NPC1 (0.67) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL32682873 | 0.72 | LDHA (0.65) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30081970 | 0.72 | TDO2 (0.69) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21290149 | 0.70 | IDO1 (0.48) | IDO1TDO2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9505812 | 0.69 | NPC1 (0.66) | IDO1TDO2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670805-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028484-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-31 | — | — | WO | disclosed |