Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8810776 | 0.74 | EDNRA (0.44) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2800705 | 0.74 | SLC6A3 (0.37) | SLC6A3SLC6A2SLC6A4AKT1ESR1 | |
| SCHEMBL1457021 | 0.73 | SLC6A3 (0.46) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL1456286 | 0.72 | SLC6A3 (0.44) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL27628232 | 0.71 | SLC6A3 (0.43) | SLC6A3SLC6A2SLC6A4KCNQ2ALDH1A1 | |
| SCHEMBL6573446 | 0.70 | FAAH (0.34) | ALDH1A1 | |
| SCHEMBL1457296 | 0.70 | SLC6A3 (0.43) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL1461235 | 0.69 | SLC6A3 (0.42) | SLC6A3SLC6A2SLC6A4KCNQ2ALDH1A1 | |
| SCHEMBL7640086 | 0.69 | SLC6A3 (0.51) | SLC6A3SLC6A2SLC6A4ALDH1A1LMNA | |
| SCHEMBL6259522 | 0.68 | ACE (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |