Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 5/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017109 | 0.91 | TRPV1 (0.42) | ICMTLMNAALDH1A1GLACYP2C9 | |
| SCHEMBL5617133 | 0.83 | KDM4E (0.48) | ICMTTSHRLMNAALDH1A1GLA | |
| SCHEMBL5630993 | 0.76 | PPARD (0.48) | PPARDPPARAPPARG | |
| SCHEMBL6017371 | 0.74 | TRPV1 (0.45) | ICMTLMNATRPV1PPARDPPARA | |
| SCHEMBL6017333 | 0.73 | TRPV1 (0.48) | ICMTTRPV1KDM4EPPARDPPARA | |
| SCHEMBL6017240 | 0.72 | KDM4E (0.43) | ICMTTSHRLMNAALDH1A1GLA | |
| SCHEMBL6017456 | 0.71 | GRIN2B (0.43) | NFKB1PPARDPPARAPPARG | |
| SCHEMBL27642697 | 0.71 | GRIN1 (0.40) | NFKB1PPARDPPARAPPARG | |
| SCHEMBL6287980 | 0.71 | TSHR (0.67) | ICMTTSHRLMNAALDH1A1GLA | |
| SCHEMBL6489229 | 0.69 | PPARD (0.70) | PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |