Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 11/20 | 0.45 |
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6017575 | 0.91 | TRPV1 (0.46) | TRPV1PPARDPPARAPPARGHCRTR2 | |
| SCHEMBL5617133 | 0.88 | KDM4E (0.48) | TRPV1KDM4EPPARDPPARAPPARG | |
| SCHEMBL6017240 | 0.83 | KDM4E (0.43) | TRPV1KDM4EPPARDPPARAPPARG | |
| SCHEMBL5617389 | 0.82 | PPARD (0.45) | TRPV1PPARDPPARAPPARG | |
| SCHEMBL1998011 | 0.79 | TRPV1 (0.42) | TRPV1KDM4EPPARDPPARAPPARG | |
| SCHEMBL6017371 | 0.79 | TRPV1 (0.45) | TRPV1PPARDPPARAPPARGHCRTR2 | |
| SCHEMBL6223101 | 0.77 | PPARA (0.57) | KDM4EPPARDPPARAPPARG | |
| SCHEMBL5617383 | 0.77 | PPARD (0.43) | PPARDPPARAPPARG | |
| SCHEMBL6017234 | 0.77 | PPARD (0.63) | PPARDPPARAPPARG | |
| SCHEMBL6221808 | 0.76 | PPARG (0.64) | KDM4EPPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682535-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005049606-A1 | HETEROARYL DERIVATIVES AS PPAR ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-02 | — | — | WO | disclosed |