Propionamide

Propionamide

SCHEMBL6017481

CCC(N)=O.O=C(CC1CCCCC1)NO

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.50
HPGD P15428 2/20 0.50
EPHX1 P07099 1/20 0.50
RAB9A P51151 6/20 0.42
NPC1 O15118 4/20 0.42
EPHX2 P34913 3/20 0.42
AAK1 Q2M2I8 1/20 0.42
P2RX7 Q99572 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
CTSD P07339 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4179001 0.87 KMT2A (0.63) KMT2AHPGDEPHX1RAB9ANPC1
SCHEMBL4179368 0.87 KMT2A (0.63) KMT2AHPGDEPHX1RAB9ANPC1
SCHEMBL13043831 0.84 KMT2A (0.59) KMT2AHPGDEPHX1RAB9ANPC1
SCHEMBL6274645 0.74 HPGD (0.53) KMT2AHPGDEPHX1RAB9ANPC1
SCHEMBL11356392 0.74 HPGD (0.53) KMT2AHPGDEPHX1RAB9ANPC1
SCHEMBL24986 0.74 EPHX1 (0.50) KMT2AHPGDEPHX1EPHX2
SCHEMBL29291474 0.74 EPHX1 (0.50) KMT2AHPGDEPHX1EPHX2
SCHEMBL29291470 0.74 EPHX1 (0.50) KMT2AHPGDEPHX1EPHX2
SCHEMBL20379771 0.74 EPHX1 (0.50) KMT2AHPGDEPHX1EPHX2
SCHEMBL1327157 0.74 EPHX1 (0.50) KMT2AHPGDEPHX1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1727516-A1 COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID DSM IP Assets B.V. (NL) 2006-12-06 EP disclosed
WO-2005092283-A1 COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID DSM IP ASSETS B.V. (NL) 2005-10-06 WO disclosed