SCHEMBL6017524

SCHEMBL6017524

CSc1ccc(CNC(C)=O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.59
EPHX2 P34913 1/20 0.58
NR1H4 Q96RI1 1/20 0.58
HDAC1 Q13547 2/20 0.56
HDAC6 Q9UBN7 1/20 0.56
MAPT P10636 4/20 0.55
RAB9A P51151 3/20 0.55
NPC1 O15118 2/20 0.55
ALDH1A1 P00352 2/20 0.54
POLB P06746 1/20 0.54
LMNA P02545 1/20 0.51
MEN1 O00255 2/20 0.49
HTT P42858 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
MLLT3 P42568 1/20 0.48
MLLT1 Q03111 1/20 0.48
ACACB O00763 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12133623 0.85 KMT2A (0.76) KMT2AHDAC1HDAC6MAPTRAB9A
SCHEMBL29260504 0.85 MAPT (0.59) KMT2AEPHX2NR1H4MAPTRAB9A
SCHEMBL22059617 0.81 LMNA (0.56) KMT2AEPHX2NR1H4MAPTRAB9A
SCHEMBL22059618 0.80 ERCC1 (0.57) KMT2AEPHX2NR1H4MAPTRAB9A
SCHEMBL11081323 0.79 PTPRZ1 (0.69) KMT2AEPHX2NR1H4HDAC1HDAC6
SCHEMBL2053212 0.79 MAPT (0.62) KMT2AHDAC1HDAC6MAPTRAB9A
SCHEMBL1951513 0.78 KMT2A (0.66) KMT2AEPHX2HDAC1HDAC6MAPT
SCHEMBL3612557 0.78 KMT2A (0.66) KMT2ANR1H4HDAC1HDAC6MAPT
SCHEMBL3612554 0.78 KMT2A (0.66) KMT2AHDAC1HDAC6MAPTRAB9A
SCHEMBL171709 0.78 KMT2A (0.66) KMT2AHDAC1HDAC6MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1708992-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES Pfizer Limited (GB) 2006-10-11 EP claimed
WO-2005080324-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES PFIZER LIMITED (GB) 2005-09-01 WO claimed
EP-1730103-A1 FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR Pfizer Limited (GB) 2006-12-13 EP disclosed
EP-1708992-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES Pfizer Limited (GB) 2006-10-11 EP disclosed
EP-1465869-A4 MODULATORS OF LXR X CEPTOR THERAPEUTICS INC (US) 2005-12-28 EP disclosed
WO-2005092840-A1 FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR PFIZER LIMITED (GB) 2005-10-06 WO disclosed
WO-2005080324-A1 SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES PFIZER LIMITED (GB) 2005-09-01 WO disclosed
EP-1465869-A1 MODULATORS OF LXR X-Ceptor Therapeutics, Inc. (US) 2004-10-13 EP disclosed
WO-2003059884-A1 MODULATORS OF LXR X-CEPTOR THERAPEUTICS, INC. (US) 2003-07-24 WO disclosed