Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573446 | 0.84 | FAAH (0.34) | MAPT | |
| SCHEMBL9811868 | 0.83 | HSD17B10 (0.32) | HSD17B10 | |
| SCHEMBL3658794 | 0.82 | NPSR1 (0.36) | MAPTHSD17B10 | |
| SCHEMBL4714174 | 0.82 | NR1H2 (0.34) | — | |
| SCHEMBL6958668 | 0.81 | NR1H2 (0.33) | — | |
| SCHEMBL4711556 | 0.81 | ALDH1A1 (0.31) | MAPT | |
| SCHEMBL7275965 | 0.81 | NR1H2 (0.35) | TP53MAPT | |
| SCHEMBL2552479 | 0.79 | ABCG2 (0.32) | TP53MAPTALOX15HSD17B10 | |
| SCHEMBL5691656 | 0.79 | NPSR1 (0.45) | MAPT | |
| SCHEMBL5172213 | 0.77 | ABCG2 (0.35) | TP53MAPTALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684694-A2 | AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005051304-A2 | AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |