Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10438568 | 0.84 | TSHR (0.54) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL13536803 | 0.82 | MAPT (0.55) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL11663385 | 0.78 | TSHR (0.54) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL19938077 | 0.78 | TSHR (0.54) | TSHRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1069671 | 0.76 | TSHR (0.59) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL7830860 | 0.76 | TSHR (0.54) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL2929031 | 0.76 | TDP1 (0.62) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL30989211 | 0.76 | TDP1 (0.62) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL12798874 | 0.76 | TDP1 (0.62) | TSHRTDP1MAPTALDH1A1MEN1 | |
| SCHEMBL13536804 | 0.75 | ALDH1A1 (0.45) | TSHRTDP1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709012-A1 | 6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE)POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005054210-A1 | 6-SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-16 | — | — | WO | disclosed |