Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL861172 | 1.00 | CYP3A4 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL31399387 | 0.82 | MAPT (0.53) | MAPTGAAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL17365209 | 0.82 | MAPT (0.53) | MAPTGAAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL5048104 | 0.79 | ACACB (0.45) | — | |
| SCHEMBL10745644 | 0.78 | MIF (0.49) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL30300332 | 0.78 | MAPT (0.51) | CYP3A4ALDH1A1HSD17B10TDP1MAPT | |
| SCHEMBL140150 | 0.78 | MAPT (0.51) | CYP3A4ALDH1A1HSD17B10TDP1MAPT | |
| SCHEMBL9432285 | 0.78 | CYP3A4 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL97197 | 0.78 | NPC1 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL4656696 | 0.75 | CYP3A4 (0.45) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689747-A1 | 1H-IMIDAZO [4,5-C] QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | Novartis AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005054238-A1 | 1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2005-06-16 | — | — | WO | disclosed |