Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6018971 | 1.00 | CYP3A4 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL31399387 | 0.82 | MAPT (0.53) | MAPTGAAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL17365209 | 0.82 | MAPT (0.53) | MAPTGAAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL5048104 | 0.79 | ACACB (0.45) | — | |
| SCHEMBL10745644 | 0.78 | MIF (0.49) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL30300332 | 0.78 | MAPT (0.51) | CYP3A4ALDH1A1HSD17B10TDP1MAPT | |
| SCHEMBL140150 | 0.78 | MAPT (0.51) | CYP3A4ALDH1A1HSD17B10TDP1MAPT | |
| SCHEMBL9432285 | 0.78 | CYP3A4 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL97197 | 0.78 | NPC1 (0.48) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 | |
| SCHEMBL4656696 | 0.75 | CYP3A4 (0.45) | CYP3A4ALDH1A1HSD17B10TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114507121-A | Preparation method and product of alpha-alkenyl-alpha, alpha-difluoroaryl ketone compound | 南京工业大学 | 2022-05-17 | — | — | CN | claimed |
| CN-109704926-B | Anticancer active molecular skeleton 1, 4-eneyne compound and preparation method and application thereof | 南京工业大学 | 2022-02-08 | — | — | CN | claimed |
| US-20250136580-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2025-05-01 | — | — | US | disclosed |
| WO-2025076285-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | DELPHIA THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| CN-114507121-B | Preparation method and product of alpha-alkenyl-alpha, alpha-difluoro aryl ketone compound | 南京工业大学 | 2023-05-26 | — | — | CN | disclosed |
| CN-114507121-A | Preparation method and product of alpha-alkenyl-alpha, alpha-difluoroaryl ketone compound | 南京工业大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-109704926-B | Anticancer active molecular skeleton 1, 4-eneyne compound and preparation method and application thereof | 南京工业大学 | 2022-02-08 | — | — | CN | disclosed |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | disclosed |
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-10-14 | — | — | US | disclosed |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-20 | — | — | US | disclosed |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-04-20 | — | — | US | disclosed |
| US-4760087-A | 5-lipoxygenase inhibitor | GRUENENTHAL GMBH (DE) | 1988-07-26 | — | — | US | disclosed |
| EP-0202529-A2 | Phenol derivatives, pharmaceutical compositions containing them and processes for the preparation of these compounds and pharmaceutical compositions | Grünenthal GmbH (DE) | 1986-11-26 | — | — | EP | disclosed |
| US-4515768-A | STABILIZER AGAINST THERMAL DECOMPOSITION | AIRWICK INDUSTRIES, INC. (US) | 1985-05-07 | — | — | US | disclosed |
| EP-0036385-B1 | INSECTICIDAL VAPOUR-EMITTING COMPOSITIONS ON THE BASIS OF PYRETHRINOIDS | Airwick AG (CH) | 1984-05-02 | — | — | EP | disclosed |
| US-4439415-A | PYRETHRINOID AND ABSORPTIVE SUBSTRATE | AIRWICK INDUSTRIES, INC. (US) | 1984-03-27 | — | — | US | disclosed |
| EP-0036385-A2 | Insecticidal vapour-emitting compositions on the basis of pyrethrinoids | Airwick AG (CH) | 1981-09-23 | — | — | EP | disclosed |
| US-4209517-A | α-Ethylenic alcohols and ketones, their preparation, and their use as medicaments | UNICLER (FR) | 1980-06-24 | — | — | US | disclosed |
| US-4037353-A | Device for emitting vapors of active substance | AIRWICK INDUSTRIES, INC. (US) | 1977-07-26 | — | — | US | disclosed |
| US-4037352-A | PYRETHRINOIDS | AIRWICK INDUSTRIES, INC. (US) | 1977-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317107-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | CYP3A4 4805/4885ALDH1A1 3459/4885HSD17B10 2643/4885 |
| US-10981896-B2 | Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase | MELK, HIPK1, HIPK3 | CYP3A4 4783/4885ALDH1A1 2911/4885HSD17B10 2489/4885 |
| US-20250136580-A1 | INDOLINONE DERIVATIVES AS INHIBITORS OF MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | MELK, HIPK1, HIPK3 | CYP3A4 4805/4885ALDH1A1 3459/4885HSD17B10 2643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.