Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6019444 | 0.85 | CA1 (0.41) | — | |
| SCHEMBL3811042 | 0.84 | CA1 (0.42) | — | |
| SCHEMBL2470118 | 0.80 | CA2 (0.44) | — | |
| SCHEMBL28517671 | 0.78 | EED (0.56) | EEDKMT2ACHRNB2CHRNA4HRH4 | |
| SCHEMBL11633199 | 0.78 | EED (0.56) | EEDKMT2ACHRNB2CHRNA4HRH4 | |
| Hydrochloric Acid SCHEMBL4740172 | 0.76 | HTR6 (0.53) | KMT2AHTR6 | |
| SCHEMBL2423746 | 0.75 | PARP1 (0.52) | EEDKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL28238727 | 0.75 | PARP1 (0.52) | EEDKMT2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL3466546 | 0.75 | EED (0.56) | EEDKMT2ACHRNB2CHRNA4HRH4 | |
| SCHEMBL19908818 | 0.75 | EED (0.56) | EEDKMT2ACHRNB2CHRNA4HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613304-A1 | DPP-IV INHIBITORS | Graffinity Pharmaceuticals Aktiengesellschaft (DE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2005056003-A1 | DPP-IV INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2005-06-23 | — | — | WO | disclosed |