Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17378584 | 0.81 | CYP1A2 (0.40) | CYP1A2GLAGRM2HSD11B1NR1H2 | |
| SCHEMBL28331893 | 0.80 | CYP1A2 (0.40) | CYP1A2GLAHSD11B1NR1H2NR1H3 | |
| SCHEMBL15000593 | 0.80 | TLR8 (0.43) | CYP1A2GLANR1H2NR1H3MAPK1 | |
| SCHEMBL15520213 | 0.78 | CYP1A2 (0.48) | CYP1A2GLAENPP3ENPP1HSD11B1 | |
| SCHEMBL6950074 | 0.78 | TLR8 (0.44) | CYP1A2GLAGRM2NPC1RAB9A | |
| SCHEMBL7876217 | 0.75 | SMN1; SMN2 (0.50) | GRM2ENPP3ENPP1HSD11B1NPC1 | |
| SCHEMBL22286053 | 0.74 | LMNA (0.40) | CYP1A2GRM2ENPP3ENPP1ALDH1A1 | |
| SCHEMBL7887559 | 0.74 | GRM2 (0.38) | GRM2NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL31005200 | 0.74 | MMP12 (0.47) | GRM2BACE1 | |
| SCHEMBL18341299 | 0.74 | MMP12 (0.47) | GRM2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613626-A1 | CYCLIC BENZIMIDAZOLES | ALTANA Pharma AG (DE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087701-A1 | CYCLIC BENZIMIDAZOLES | ALTANA PHARMA AG (DE) | 2004-10-14 | — | — | WO | disclosed |