Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.59 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | GCG | P01275 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | GIPR | P48546 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529722 | 0.83 | PIK3CD (0.65) | PIK3CDMPOCYSLTR1PKMEPHX1 | |
| SCHEMBL4770249 | 0.82 | PIK3CD (0.54) | PIK3CDMPOCYSLTR1PKMPDE4D | |
| SCHEMBL4766399 | 0.78 | KMT2A (0.48) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL5744199 | 0.78 | MPO (0.57) | PIK3CDMPOCYSLTR1PKMKMT2A | |
| SCHEMBL5217280 | 0.76 | PIK3CD (0.54) | PIK3CDMPOCYSLTR1PKMGCG | |
| SCHEMBL5212891 | 0.76 | PIK3CD (0.47) | PIK3CDMPOCYSLTR1PKMEPHX1 | |
| SCHEMBL4942765 | 0.76 | PIK3CD (0.54) | PIK3CDMPOCYSLTR1PKMGCG | |
| SCHEMBL5214659 | 0.76 | PIK3CD (0.57) | PIK3CDMPOCYSLTR1PKMGCG | |
| SCHEMBL5214629 | 0.75 | PIK3CD (0.51) | PIK3CDMPOCYSLTR1PKMGCG | |
| SCHEMBL6025026 | 0.75 | MPO (0.44) | PIK3CDMPOCYSLTR1PKMPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636210-A1 | CYCLOALKYL AND HETEROCYCLOALKYL SUBSTITUTED BENZOTHIOPHENES AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108713-A1 | CYCLOALKYL AND HETEROCYCLOALKYL SUBSTITUTED BENZOTHIOPHENES AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-16 | — | — | WO | disclosed |