Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | QPCT | Q16769 | 10/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6021133 | 1.00 | NLRP3 (0.34) | NLRP3QPCTPIK3CAMTORHDAC1 | |
| SCHEMBL6021836 | 0.82 | GRM2 (0.37) | NLRP3 | |
| SCHEMBL6021832 | 0.82 | GRM2 (0.37) | NLRP3 | |
| SCHEMBL3328728 | 0.76 | MAOA (0.49) | — | |
| SCHEMBL3370435 | 0.76 | MAOA (0.49) | — | |
| SCHEMBL8251549 | 0.73 | MAPT (0.39) | QPCTPIK3CAMTORIDH1 | |
| SCHEMBL13862087 | 0.72 | PIK3CA (0.39) | QPCTPIK3CAMTORHDAC1HDAC8 | |
| SCHEMBL8256262 | 0.72 | PIK3CA (0.37) | QPCTPIK3CAMTORHDAC1HDAC8 | |
| SCHEMBL8259871 | 0.70 | CCR1 (0.41) | PIK3CAMTORHDAC1HDAC8HDAC6 | |
| SCHEMBL15152621 | 0.70 | IDH1 (0.35) | QPCTPIK3CAMTORHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646629-A2 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005398-A2 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| EP-1385834-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | Merck & Co., Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2003027083-A1 | BICYCLO[3,1,0]HEXANE CONTAINING OXAZOLIDINONE ANTIBIOTIC AND DERIVATIVES THEREOF | MERCK & CO., INC. (US) | 2003-04-03 | — | — | WO | disclosed |