Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17371365 | 0.86 | ALOX15 (0.57) | ALOX15KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4685577 | 0.85 | ALOX15 (0.54) | ALOX15KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL4685579 | 0.85 | ALOX15 (0.54) | ALOX15KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL7021631 | 0.82 | GPR84 (0.47) | KMT2AGPR84GAAHTTKDM4E | |
| SCHEMBL7022821 | 0.82 | GPR84 (0.47) | KMT2AGPR84GAAHTTKDM4E | |
| SCHEMBL5045978 | 0.78 | GPR84 (0.50) | KMT2AGPR84GAAHTTKDM4E | |
| SCHEMBL11334284 | 0.78 | SMN1; SMN2 (0.51) | ALOX15KMT2AGPR84GAAHTT | |
| SCHEMBL8363955 | 0.78 | ALOX15 (0.66) | ALOX15KMT2AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL4681250 | 0.77 | ALOX15 (0.60) | ALOX15KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL4681246 | 0.77 | ALOX15 (0.60) | ALOX15KMT2AKDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725239-A1 | 4-(SULFANYL-PYRIMIDIN-4-YLMETHYL)-MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005094828-A1 | 4- (SULFANYL-PYRIMIDIN-4-YLMETHYL) -MORPHOLINE DERIVATIVES AND RELATED COMPOUNDS AS GABA RECEPTOR LIGANDS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND EPILEPSY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-13 | — | — | WO | disclosed |