Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048799 | 0.84 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL5043583 | 0.78 | TSHR (0.38) | CRHR1TP53SMN1; SMN2 | |
| SCHEMBL5043187 | 0.77 | CRHR1 (0.37) | CRHR1RXRARXRBRXRG | |
| SCHEMBL5047003 | 0.77 | POLB (0.48) | CRHR1RXRARXRBRXRG | |
| SCHEMBL5039430 | 0.77 | CRHR1 (0.36) | CRHR1RXRARXRBRXRGTP53 | |
| SCHEMBL5043423 | 0.76 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL14049594 | 0.76 | MAPT (0.33) | CRHR1RXRARXRBRXRGSMN1; SMN2 | |
| SCHEMBL14031202 | 0.76 | PKM (0.36) | CRHR1SMN1; SMN2NPSR1 | |
| SCHEMBL5044224 | 0.75 | CRHR1 (0.30) | CRHR1 | |
| SCHEMBL5044137 | 0.75 | CRHR1 (0.31) | CRHR1RXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718299-A1 | HETEROCYCLIC GABA-A SUBTYPE SELECTIVE RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005077363-A1 | HETEROCYCLIC GABA-A SUBTYPE SELECTIVE RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-25 | — | — | WO | disclosed |