Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.41 |
| ▸ | C1S | P09871 | 3/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | KLK1 | P06870 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12971526 | 0.78 | PARP1 (0.47) | BLMRECQLKMT2A | |
| SCHEMBL1950632 | 0.77 | PRSS1 (0.50) | F12LMNAPRSS1PRSS3PRSS2 | |
| SCHEMBL1949948 | 0.77 | PRSS1 (0.41) | F12LMNAPRSS1PRSS3PRSS2 | |
| SCHEMBL1950671 | 0.77 | LMNA (0.43) | F12LMNAPRSS1PRSS3PRSS2 | |
| SCHEMBL8170563 | 0.72 | F10 (0.38) | F12LMNAPRSS1PRSS3PRSS2 | |
| SCHEMBL7985427 | 0.72 | PRSS1 (0.41) | F12PRSS1PRSS3PRSS2F2 | |
| SCHEMBL7985574 | 0.72 | PRSS1 (0.49) | PRSS1PRSS3PRSS2C1SPLG | |
| SCHEMBL8170922 | 0.72 | PRSS1 (0.41) | F12PRSS1PRSS3PRSS2F2 | |
| SCHEMBL4587392 | 0.72 | PLAU (0.50) | PRSS1F2PLGPLAUKLKB1 | |
| SCHEMBL6022788 | 0.72 | PRSS1 (0.48) | F12LMNAPRSS1PRSS3PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105559-B2 | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2006-09-12 | — | — | US | disclosed |
| US-20050267123-A1 | 6-Membered heterocyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-12-01 | — | — | US | disclosed |
| US-6969715-B2 | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-11-29 | — | — | US | disclosed |
| US-20050239860-A1 | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION (US) | 2005-10-27 | — | — | US | disclosed |
| EP-1438292-A1 | 6-MEMBERED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1432687-A2 | SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | Pharmacia Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003093242-A2 | SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-11-13 | — | — | WO | disclosed |
| US-20030162776-A1 | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2003-08-28 | — | — | US | disclosed |
| US-20030139405-A1 | 6-Membered heterocyclic compounds useful for selective inhibition of the coagulation cascade | PHARMACIA CORPORATION | 2003-07-24 | — | — | US | disclosed |
| WO-2003029216-A1 | 6-MEMBERED HETEROCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162776-A1 | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade | TFPI, F2, SERPINC1 | F12 16/4885LMNA 872/4885PRSS1 39/4885 |
| US-20050267123-A1 | 6-Membered heterocyclic compounds useful for selective inhibition of the coagulation cascade | TFPI, F2, SERPINC1 | F12 12/4885LMNA 1275/4885PRSS1 55/4885 |
| US-20030139405-A1 | 6-Membered heterocyclic compounds useful for selective inhibition of the coagulation cascade | TFPI, F2, SERPINC1 | F12 12/4885LMNA 1275/4885PRSS1 55/4885 |
| US-20050239860-A1 | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade | TFPI, F2, SERPINC1 | F12 16/4885LMNA 872/4885PRSS1 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.