Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335649 | 0.98 | ALOX5 (0.49) | ALOX5PTGS2PPARAHTR2APPARG | |
| SCHEMBL4409587 | 0.93 | ALOX5 (0.42) | ALOX5PTGS2PPARAHTR2AELANE | |
| SCHEMBL8475524 | 0.86 | HMGCR (0.43) | ALOX5PTGS2ALDH1A1ELANE | |
| SCHEMBL7107986 | 0.85 | CNR2 (0.41) | MEN1ALDH1A1KMT2ATHRATHRB | |
| SCHEMBL7112377 | 0.85 | CNR2 (0.41) | MEN1ALDH1A1KMT2ATHRATHRB | |
| SCHEMBL7108160 | 0.85 | CNR2 (0.41) | MEN1ALDH1A1KMT2ATHRATHRB | |
| SCHEMBL7106248 | 0.85 | CNR2 (0.41) | MEN1ALDH1A1KMT2ATHRATHRB | |
| SCHEMBL11560689 | 0.85 | ALOX5 (0.49) | ALOX5PTGS2PPARAHTR2APPARG | |
| SCHEMBL27980507 | 0.83 | TAAR1 (0.43) | — | |
| SCHEMBL8347519 | 0.81 | TAAR1 (0.33) | ALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880523-B1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-0880523-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997029109-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-14 | — | — | WO | disclosed |