Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023051 | 0.88 | USP2 (0.52) | HRH4USP30AURKAPDPK1ROCK1 | |
| SCHEMBL6510066 | 0.80 | LMNA (0.53) | ADORA2AADORA1HRH4AURKAPDPK1 | |
| SCHEMBL6023493 | 0.79 | JAK2 (0.45) | ADORA2APDE4DHRH4HRH3USP30 | |
| Hydrochloric Acid SCHEMBL604938 | 0.78 | HRH4 (0.55) | HRH4HRH3 | |
| SCHEMBL6023878 | 0.75 | LMNA (0.55) | HRH4HRH3LMNATSHRHTT | |
| SCHEMBL5076737 | 0.75 | LMNA (0.55) | HRH4HRH3LMNATSHRHTT | |
| SCHEMBL1775505 | 0.75 | LMNA (0.55) | HRH4HRH3LMNATSHRHTT | |
| SCHEMBL4392707 | 0.75 | HRH4 (0.64) | HRH4HRH3 | |
| SCHEMBL12483311 | 0.75 | CCNC (0.43) | ADORA2AADORA1USP30HTR2A | |
| SCHEMBL17745899 | 0.75 | CCNC (0.43) | ADORA2AADORA1USP30HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654237-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | Bayer HealthCare AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014556-A1 | 2-AMINOPYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-02-17 | — | — | WO | disclosed |
| EP-1505064-A1 | 2-Aminopyrimidine derivatives | Bayer HealthCare AG (DE) | 2005-02-09 | — | — | EP | disclosed |