Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.34 |
| ▸ | EPOR | P19235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024794 | 1.00 | POLB (0.38) | POLBCNR2TAS2R14EPORALDH1A1 | |
| SCHEMBL3458170 | 0.87 | POLB (0.38) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL3457756 | 0.87 | POLB (0.38) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL3458080 | 0.82 | BACE1 (0.40) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL3457301 | 0.82 | BACE1 (0.40) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL6024693 | 0.82 | BACE1 (0.40) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL6024628 | 0.82 | BACE1 (0.40) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL3026226 | 0.73 | TAS2R14 (0.46) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL3026229 | 0.73 | TAS2R14 (0.46) | POLBCNR2TAS2R14ALDH1A1LMNA | |
| SCHEMBL2173108 | 0.72 | LMNA (0.37) | POLBALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |