Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27487023 | 0.90 | TSHR (0.37) | TSHRCYP3A4ALDH1A1HPGD | |
| SCHEMBL27543355 | 0.88 | TSHR (0.38) | TSHRCYP3A4SMN1; SMN2ALDH1A1TP53 | |
| Hydrochloric Acid SCHEMBL28418892 | 0.86 | TSHR (0.39) | TSHRSMN1; SMN2MAPTHPGDGALR3 | |
| SCHEMBL27657877 | 0.84 | TSHR (0.40) | TSHRCYP3A4ALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL5385817 | 0.83 | TSHR (0.43) | TSHRCYP3A4MAPTALDH1A1MAPK1 | |
| Bromide SCHEMBL20235977 | 0.83 | TSHR (0.39) | TSHRHPGD | |
| Hydrochloric Acid SCHEMBL27618636 | 0.83 | TSHR (0.39) | TSHRSMN1; SMN2MAPTHPGDGALR3 | |
| Hydrochloric Acid SCHEMBL27662712 | 0.82 | TSHR (0.41) | TSHRCYP3A4SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL27847719 | 0.81 | TSHR (0.44) | TSHRCYP3A4MAPTALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7870981 | 0.81 | TSHR (0.41) | TSHRCYP3A4MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1891727-A | Water-soluble amphoteric copolymer, production method thereof, and application thereof | NIPPON CATALYTIC CHEM IND (JP) | 2007-01-10 | — | — | CN | disclosed |
| EP-1633573-A2 | AQUEOUS WHITE PIGMENT COMPOSITIONS | Clariant Finance (BVI) Limited (VG) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106079-A2 | AQUEOUS WHITE PIGMENT COMPOSITIONS | CLARIANT INTERNATIONAL LTD (CH) | 2004-12-09 | — | — | WO | disclosed |