Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31053271 | 0.87 | KMT2A (0.47) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL20772934 | 0.87 | KMT2A (0.47) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL21437928 | 0.85 | EGFR (0.46) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL29853167 | 0.85 | EGFR (0.46) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL2556992 | 0.85 | EGFR (0.56) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL20561914 | 0.85 | HPGD (0.41) | MAPTTP53KMT2AMEN1MAPK1 | |
| SCHEMBL2294386 | 0.84 | MAPT (0.43) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL1680849 | 0.84 | ALDH1A1 (0.45) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL12069886 | 0.84 | MAPT (0.44) | MAPTTP53KMT2AMEN1S1PR4 | |
| SCHEMBL18524117 | 0.84 | MAPT (0.43) | MAPTTP53KMT2AMEN1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | disclosed |