Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6023275 | 0.77 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL6024863 | 0.74 | NOS2 (0.39) | NOS2KDM4EPOLBALDH1A1 | |
| SCHEMBL6024808 | 0.70 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL16575419 | 0.68 | KDM4E (0.35) | NOS2KDM4EPOLBALDH1A1 | |
| SCHEMBL6024827 | 0.65 | — | — | |
| SCHEMBL6024884 | 0.65 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL6023883 | 0.65 | — | — | |
| SCHEMBL6024178 | 0.63 | — | — | |
| SCHEMBL12668092 | 0.63 | KDM4E (0.32) | NOS2KDM4EPOLB | |
| SCHEMBL6024281 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880523-B1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-0880523-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997029109-A1 | PYRAZOLOPYRIMIDINES AS CRF RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-08-14 | — | — | WO | disclosed |