Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609371 | 0.79 | ALDH1A1 (0.42) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL3988622 | 0.79 | NOTUM (0.38) | AKR1B1ALDH1A1KMT2AHPGDTDP1 | |
| SCHEMBL11727844 | 0.77 | ALDH1A1 (0.54) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL3814670 | 0.73 | KLKB1 (0.38) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL11299831 | 0.72 | PTGS2 (0.58) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL11711178 | 0.72 | PTGS2 (0.58) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL11369958 | 0.72 | PTGS2 (0.48) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL8606633 | 0.72 | PTGS2 (0.61) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL7681255 | 0.70 | PTGS2 (0.51) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL11717591 | 0.70 | PTGS2 (0.58) | PTGS2CXCL8AKR1B1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060154954-A1 | Combinations and use of selected pharmaceutically active compounds | ALTANA PHARMA AG (DE) | 2006-07-13 | — | — | US | claimed |
| EP-0006845-A1 | Pharmaceutical composition comprising a 5-aroyl-1-C1-5 alkyl-pyrrole-2-acetic acid compound and acetaminophen or acetylsalicylic acid | McNeilab, Inc. (US) | 1980-01-23 | — | — | EP | disclosed |