Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PYGL | P06737 | 6/20 | 0.38 |
| ▸ | PYGM | P11217 | 6/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320169 | 0.94 | HCAR3 (0.43) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL6025080 | 0.87 | RAF1 (0.39) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4334360 | 0.85 | MEN1 (0.45) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4323736 | 0.84 | PDGFRA (0.39) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4339448 | 0.79 | MEN1 (0.43) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL4321912 | 0.79 | HTT (0.47) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL2886701 | 0.78 | HCAR3 (0.53) | KDRPYGLPYGMHCAR3MEN1 | |
| SCHEMBL2891203 | 0.77 | MEN1 (0.41) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL2891200 | 0.74 | MEN1 (0.40) | LMNACASP3SENP8SENP7SENP6 | |
| SCHEMBL9395834 | 0.71 | ALDH1A1 (0.54) | LMNAHCAR3MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682126-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005037273-A1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS INHIBITORS OF RAF KINASE | CHIRON CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |