Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1111841 | 0.89 | PSIP1 (0.55) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL9827142 | 0.83 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL777886 | 0.81 | PSIP1 (0.64) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL7302021 | 0.80 | PSIP1 (0.52) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL9834726 | 0.80 | ALDH1A1 (0.62) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL2445501 | 0.80 | PSIP1 (0.61) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| Benzene SCHEMBL6390523 | 0.80 | PSIP1 (0.61) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL16788368 | 0.79 | PSIP1 (0.43) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10410597 | 0.79 | CHRM2 (0.45) | PSIP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL10616984 | 0.78 | PSIP1 (0.59) | PSIP1HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685119-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049594-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |