⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24772122 | 0.77 | — | — | |
| SCHEMBL925857 | 0.75 | — | — | |
| SCHEMBL15151214 | 0.73 | — | — | |
| SCHEMBL20031203 | 0.71 | — | — | |
| SCHEMBL21531775 | 0.71 | — | — | |
| SCHEMBL23543063 | 0.71 | — | — | |
| SCHEMBL6025538 | 0.71 | — | — | |
| SCHEMBL21788078 | 0.69 | — | — | |
| SCHEMBL18431399 | 0.69 | — | — | |
| SCHEMBL23521071 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222522-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| US-20210155634-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-05-27 | — | — | US | disclosed |
| US-10954202-B2 | Protein tyrosine phosphatase inhibitors and methods of use thereof | ABBVIE INC. (US) | 2021-03-23 | — | — | US | disclosed |
| US-10723698-B2 | Inhibitors of PRMT5 and methods of their use | THE OHIO STATE UNIVERSITY (US) | 2020-07-28 | — | — | US | disclosed |
| US-20190270707-A1 | INHIBITORS OF PRMT5 AND METHODS OF THEIR USE | THE OHIO STATE UNIVERSITY | 2019-09-05 | — | — | US | disclosed |
| US-20190138127-A1 | WINDOW FOR DISPLAY DEVICE, METHOD FOR FABRICATING THE SAME AND DISPLAY DEVICE INCLUDING THE SAME | SAMSUNG DISPLAY CO., LTD. (KR) | 2019-05-09 | — | — | US | disclosed |
| EP-3233836-B1 | INDAZOLE SULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) | GALDERMA RES & DEV (FR) | 2019-01-30 | — | — | EP | disclosed |
| US-20120238540-A1 | AMINO-PYRIMIDINE COMPOUNDS AS INHIBITORS OF IKK EPSILON AND/OR TBK1 | MYREXIS, INC. (US) | 2012-09-20 | — | — | US | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
| EP-1716141-A1 | BENZOPYRAN DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | Université de Liège (BE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005075463-A1 | BENZOPYRAN DERIVATIVES, METHOD OF PRODUCTION AND USE THEREOF | UNIVERSITE DE LIEGE (BE) | 2005-08-18 | — | — | WO | disclosed |