Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.52 |
| ▸ | CCND1 | P24385 | 6/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL635643 | 0.78 | CDK4 (0.71) | CDK4CCND1CHEK1KITACHE | |
| SCHEMBL30448628 | 0.78 | KIF11 (0.59) | CHEK1KITPDGFRAFGFR3ACHE | |
| SCHEMBL14329664 | 0.76 | ACHE (0.49) | CDK4CCND1CHEK1ACHEKIF11 | |
| SCHEMBL14126239 | 0.73 | CDK4 (0.47) | CDK4CCND1CHEK1KITPDGFRA | |
| SCHEMBL29723882 | 0.71 | CHUK (0.65) | CHEK1KITPDGFRAFGFR3ACHE | |
| SCHEMBL3191588 | 0.71 | CHUK (0.65) | CHEK1KITPDGFRAFGFR3ACHE | |
| SCHEMBL11071687 | 0.70 | HASPIN (0.48) | CHEK1KITPDGFRAFGFR3ACHE | |
| SCHEMBL4822655 | 0.69 | KIF11 (0.58) | CHEK1KIF11 | |
| SCHEMBL8120408 | 0.69 | CDK4 (1.00) | CDK4CCND1CHEK1KITACHE | |
| SCHEMBL29848541 | 0.69 | CDK4 (1.00) | CDK4CCND1CHEK1KITACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663219-A2 | USE OF INDOLE-DERIVED COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT THAT CAN BE USED TO TREAT DISEASES RELATED TO THE SPLICING PROCESS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023255-A2 | USE OF INDOLE-DERIVED COMPOUNDS FOR THE PREPARATION OF A MEDICAMENT THAT CAN BE USED TO TREAT DISEASES RELATED TO THE SPLICING PROCESS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2005-03-17 | — | — | WO | disclosed |