SCHEMBL6026869

SCHEMBL6026869

CC(C)(C)C(N)CCn1cc(C(=O)O)c(-c2ccc(Cl)cc2Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
TP53 P04637 1/20 0.38
TSHR P16473 1/20 0.38
CASP1 P29466 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
CYP2C9 P11712 1/20 0.36
KMT2A Q03164 1/20 0.36
MYC P01106 1/20 0.35
NR4A1 P22736 1/20 0.35
NOTUM Q6P988 1/20 0.35
MARS1 P56192 2/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
SRD5A2 P31213 1/20 0.34
DPP4 P27487 3/20 0.34
DHODH Q02127 1/20 0.34
DPP8 Q6V1X1 1/20 0.34
DPP7 Q9UHL4 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3261753 0.80 ALDH1A1 (0.43) ALDH1A1TP53TSHRCASP1SMN1; SMN2
SCHEMBL6265340 0.74 GSK3B (0.44) ALDH1A1SMN1; SMN2POLB
SCHEMBL1219591 0.71 CNR1 (0.43) DPP4DPP8
SCHEMBL6027697 0.64 ALDH1A1 (0.56) ALDH1A1TP53TSHRCASP1SMN1; SMN2
SCHEMBL11549938 0.64 HSD11B1 (0.38) TP53SMN1; SMN2MEN1POLBCYP2C9
SCHEMBL22188198 0.63 KMT2A (0.36) ALDH1A1SMN1; SMN2MEN1POLBKMT2A
SCHEMBL442223 0.63 ALDH1A1 (0.58) ALDH1A1TP53TSHRCASP1SMN1; SMN2
SCHEMBL9558834 0.62 TSHR (0.68) ALDH1A1TP53TSHRCASP1SMN1; SMN2
SCHEMBL3261750 0.62 SRD5A2 (0.40) MEN1POLBCYP2C9KMT2AMARS1
SCHEMBL19514758 0.61 ALDH1A1 (0.71) ALDH1A1TP53TSHRCASP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1618127-A2 THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS CHIRON CORPORATION (US) 2006-01-25 EP disclosed
EP-1608369-A2 USE OF ORGANIC COMPOUNDS FOR IMMUNOPOTENTIATION CHIRON CORPORATION (US) 2005-12-28 EP disclosed
EP-1537099-A1 PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 CHIRON CORPORATION (US) 2005-06-08 EP disclosed
WO-2004092360-A2 THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS CHIRON CORPORATION (US) 2004-10-28 WO disclosed
WO-2004087153-A2 USE OF ORGANIC COMPOUNDS FOR IMMUNOPOTENTIATION CHIRON CORPORATION (US) 2004-10-14 WO disclosed
WO-2004018455-A1 PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 CHIRON CORPORATION (US) 2004-03-04 WO disclosed