Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886857 | 0.88 | EPHX2 (0.43) | EPHX2RIPK1ALDH1A1HPGDTSHR | |
| SCHEMBL6026685 | 0.82 | PTPN1 (0.44) | BRD4ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL6026823 | 0.82 | NPC1 (0.45) | BRD4SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6027333 | 0.76 | BRD4 (0.42) | BRD4ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6027185 | 0.75 | PTPN1 (0.44) | BRD4ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL6879816 | 0.74 | NPC1 (0.47) | RIPK1HPGDSMN1; SMN2KMT2AMAPKAPK2 | |
| SCHEMBL6026031 | 0.74 | MEN1 (0.52) | RIPK1SMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL6026353 | 0.73 | EPHX2 (0.51) | EPHX2SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL6026524 | 0.73 | EPHX2 (0.47) | EPHX2RIPK1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL6026920 | 0.73 | EPHX2 (0.47) | EPHX2RIPK1HPGDSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613310-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | Avanir Pharmaceuticals (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091610-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | AVANIR PHARMACEUTICALS (US) | 2004-10-28 | — | — | WO | disclosed |