Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | NR2E3 | Q9Y5X4 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026685 | 0.93 | PTPN1 (0.44) | PTPN1PTPN2BRD4KITKDR | |
| SCHEMBL6026610 | 0.91 | BRD4 (0.44) | PTPN1PTPN2BRD4KITKDR | |
| SCHEMBL6027150 | 0.88 | BRD4 (0.43) | PTPN1PTPN2BRD4HPGDKDM4E | |
| SCHEMBL6027333 | 0.84 | BRD4 (0.42) | PTPN1PTPN2BRD4NR2E3ALDH1A1 | |
| SCHEMBL6887912 | 0.83 | NPSR1 (0.45) | BRD4HPGDKDM4EALDH1A1NPC1 | |
| SCHEMBL6883829 | 0.82 | PTPN1 (0.44) | PTPN1PTPN2KITKDRFLT3 | |
| SCHEMBL6888532 | 0.81 | MAPT (0.37) | PTPN1PTPN2BRD4NR2E3ALDH1A1 | |
| SCHEMBL6026353 | 0.80 | EPHX2 (0.51) | PTPN1PTPN2NR2E3SMN1; SMN2MAPT | |
| SCHEMBL14311202 | 0.79 | PTPN1 (0.62) | PTPN1PTPN2KITKDRFLT3 | |
| SCHEMBL6028360 | 0.79 | PTPN1 (0.62) | PTPN1PTPN2KITKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613310-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | Avanir Pharmaceuticals (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091610-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | AVANIR PHARMACEUTICALS (US) | 2004-10-28 | — | — | WO | disclosed |