Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026705 | 0.85 | KMT2A (0.48) | NPC1RAB9ACYP1A2HPGDCYP2C19 | |
| SCHEMBL6027061 | 0.84 | PTPN1 (0.50) | NPC1RAB9ACYP1A2HPGDCYP2C19 | |
| SCHEMBL6028629 | 0.84 | PTPN1 (0.50) | NPC1RAB9ACYP1A2HPGDCYP2C19 | |
| SCHEMBL6026031 | 0.84 | MEN1 (0.52) | NPC1RAB9ASMN1; SMN2RIPK1PTPN1 | |
| SCHEMBL6026806 | 0.81 | EGFR (0.52) | NPC1RAB9ASMN1; SMN2RIPK1KMT2A | |
| SCHEMBL6886228 | 0.81 | EGFR (0.52) | NPC1RAB9ASMN1; SMN2RIPK1KMT2A | |
| SCHEMBL6026920 | 0.81 | EPHX2 (0.47) | NPC1RAB9ACYP1A2HPGDCYP2C19 | |
| SCHEMBL6026524 | 0.81 | EPHX2 (0.47) | NPC1RAB9ACYP1A2HPGDCYP2C19 | |
| SCHEMBL6027155 | 0.80 | HSD11B1 (0.44) | KMT2ANQO2 | |
| SCHEMBL6028026 | 0.80 | KMT2A (0.43) | NPC1RAB9ACYP1A2HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229927-A1 | Imidazole derivatives for treatment of allergic and hyperproliferative disorders | AVANIR PHARMACEUTICALS | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229927-A1 | Imidazole derivatives for treatment of allergic and hyperproliferative disorders | ICOS, TSLP, IKZF3 | NPC1 4755/4885RAB9A 3864/4885CYP1A2 2544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.