Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19539428 | 0.80 | TSHR (0.32) | PIM1DYRK1ADYRK2DYRK1BTSHR | |
| SCHEMBL1925802 | 0.78 | NOS3 (0.34) | PIM1DYRK1ADYRK2DYRK1B | |
| SCHEMBL30792371 | 0.69 | POLB (0.39) | — | |
| SCHEMBL19531833 | 0.67 | NOS3 (0.33) | — | |
| SCHEMBL1990834 | 0.65 | POLB (0.45) | DYRK1ATSHR | |
| SCHEMBL4789914 | 0.63 | CYP2A6 (0.48) | DYRK1A | |
| SCHEMBL30289670 | 0.63 | LMNA (0.43) | DYRK1ATSHR | |
| SCHEMBL1925532 | 0.62 | CCNC (0.49) | PIM1DYRK1ADYRK2DYRK1B | |
| SCHEMBL19539287 | 0.61 | AKT2 (0.48) | PIM1 | |
| SCHEMBL27462728 | 0.61 | NOTUM (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670801-A1 | PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005040171-A1 | PYRAZOLO AND IMIDAZO-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |