Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13012117 | 0.87 | HTT (0.59) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 | |
| SCHEMBL17210682 | 0.81 | CES1 (0.58) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 | |
| SCHEMBL10697795 | 0.81 | HTT (0.57) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 | |
| SCHEMBL21652156 | 0.80 | KMT2A (0.51) | HTTSMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL9791592 | 0.79 | CA2 (0.54) | CTBP2KDM4ENPC1LMNA | |
| SCHEMBL21652116 | 0.78 | ELANE (0.51) | HTTPOLBTDP1KMT2AATM | |
| SCHEMBL3628705 | 0.78 | HTT (0.68) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 | |
| SCHEMBL6182221 | 0.77 | RXRA (0.39) | SMN1; SMN2ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL7387748 | 0.76 | HTT (0.56) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 | |
| SCHEMBL9392395 | 0.76 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2CTBP2POLBLDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074770-B1 | Method of DNA vaccination | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-11 | — | — | US | claimed |
| CN-1326358-A | Method of DNA vaccination | GLAXO GROUP LTD (GB) | 2001-12-12 | — | — | CN | claimed |
| EP-1107785-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012121-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | claimed |
| US-7074770-B1 | Method of DNA vaccination | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-11 | — | — | US | disclosed |
| CN-1326358-A | Method of DNA vaccination | GLAXO GROUP LTD (GB) | 2001-12-12 | — | — | CN | disclosed |
| EP-1107785-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012121-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
| US-5508310-A | ADMINISTERING SUBSTITUTED ALDEHYDES OR KETONES WHICH CAN REACT WITH T-CELL SURFACE GROUPS TO FORM SCHIFF BASES | BURROUGHS WELLCOME CO. (US) | 1996-04-16 | — | — | US | disclosed |
| EP-0614357-A1 | IMMUNOPOTENTIATORY AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-09-14 | — | — | EP | disclosed |
| WO-1994007479-A2 | IMMUNOPOTENTIATORY AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-04-14 | — | — | WO | disclosed |