Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027333 | 0.93 | BRD4 (0.42) | BRD4NR2E3MAPTMEN1KMT2A | |
| SCHEMBL6027185 | 0.91 | PTPN1 (0.44) | BRD4NR2E3MAPTKMT2APTPN2 | |
| SCHEMBL6888532 | 0.90 | MAPT (0.37) | BRD4NR2E3MAPTMEN1KMT2A | |
| SCHEMBL6027150 | 0.87 | BRD4 (0.43) | BRD4MAPTMEN1KMT2AGAA | |
| SCHEMBL6026685 | 0.84 | PTPN1 (0.44) | BRD4NR2E3MAPTKMT2APTPN2 | |
| SCHEMBL6887196 | 0.83 | MAPT (0.37) | NR2E3MAPTMEN1KMT2AGAA | |
| SCHEMBL6887912 | 0.82 | NPSR1 (0.45) | BRD4MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6887943 | 0.77 | RAB9A (0.38) | BRD4MAPTMEN1KMT2AGAA | |
| SCHEMBL6029160 | 0.76 | PTPN1 (0.54) | PTPN2PTPN1NPC1RAB9AALDH1A1 | |
| SCHEMBL6028319 | 0.76 | PTPN1 (0.54) | PTPN2PTPN1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613310-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | Avanir Pharmaceuticals (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004091610-A1 | IMIDAZOLE DERIVATIVES FOR TREATMENT OF ALLERGIC AND HYPERPROLIFERATIVE DISORDERS | AVANIR PHARMACEUTICALS (US) | 2004-10-28 | — | — | WO | disclosed |