Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | BCR | P11274 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664324 | 0.88 | ABL1 (0.55) | KMT2AABL1BCRGSK3BKIT | |
| SCHEMBL6027815 | 0.87 | UCHL1 (0.50) | KMT2AL3MBTL1UCHL1ABL1BCR | |
| SCHEMBL4665854 | 0.78 | BACE1 (0.60) | KMT2AABL1BCRMAPTLMNA | |
| SCHEMBL12228073 | 0.77 | KMT2A (1.00) | KMT2AL3MBTL1UCHL1MAPTHTT | |
| SCHEMBL4665690 | 0.77 | POLB (0.56) | KMT2AABL1BCRHTTLMNA | |
| SCHEMBL5655423 | 0.76 | ALDH1A1 (0.66) | KMT2AABL1BCRMAPTLMNA | |
| SCHEMBL4098855 | 0.76 | MAPT (0.53) | KMT2AABL1BCRKITMAPT | |
| SCHEMBL4665753 | 0.75 | BACE1 (0.55) | ABL1BCRGSK3BKITMAPT | |
| SCHEMBL4665846 | 0.75 | BACE1 (0.59) | KMT2AABL1BCRMAPTHTT | |
| SCHEMBL4667423 | 0.74 | KIT (0.47) | KMT2AABL1BCRGSK3BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709007-A1 | N-4-(6-(HETEO)ARYL-PYRIMIDIN-4-YLAMINOPHENYL)-BENZENESULFONAMIDES AS KINASE INHIBITORS | Altana Pharma AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070900-A1 | N-4-(6- (HETEO) ARYL-PYRIMIDIN-4-YLAMINOPHENYL) -BEZENESULFONAMIDES AS KINASE INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-04 | — | — | WO | disclosed |