Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2410249 | 0.81 | KMO (0.49) | KMOFAAHSREBF2KDM4ELMNA | |
| SCHEMBL10272930 | 0.79 | KMO (0.50) | KMOFAAHSREBF2DYRK1ACLK4 | |
| SCHEMBL20137308 | 0.78 | KMO (0.63) | KMOFAAHNOTUMMAP4K4RAB9A | |
| SCHEMBL2840065 | 0.75 | KMO (0.54) | KMOFAAHKDM4ELMNAMAPT | |
| SCHEMBL2842168 | 0.73 | KMO (0.51) | KMOFAAHKDM4ELMNAMAPT | |
| SCHEMBL1257940 | 0.72 | KMO (0.58) | KMOFAAHDYRK1ACLK4MAPT | |
| SCHEMBL2840908 | 0.72 | KMO (0.50) | KMOFAAHKDM4ELMNAMAPT | |
| SCHEMBL2410164 | 0.71 | EGFR (0.38) | KMODYRK1ACLK4HTR1AHTR7 | |
| SCHEMBL25295702 | 0.69 | CYP1A2 (0.60) | KMOFAAHKDM4ELMNAMAPT | |
| SCHEMBL6845003 | 0.69 | KMO (0.54) | KMOFAAHKDM4EMAPTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1926097-B | Derivatives of heteroaryl-alkyl carbamates, preparation method thereof and use as FAAH enzyme inhibitors | SANOFI AVENTIS | 2011-06-08 | — | — | CN | disclosed |
| CN-1926097-A | Derivatives of heteroaryl-alkyl carbamates, preparation method thereof and use as FAAH enzyme inhibitors | SANOFI AVENTIS (FR) | 2007-03-07 | — | — | CN | disclosed |
| EP-1720829-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090292-A1 | DERIVATIVES OF HETEROARYL-ALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |