Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 7/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 5/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30771381 | 0.86 | CTSS (0.47) | CTSSCTSKKDM4DGPR139CTSB | |
| SCHEMBL31724229 | 0.85 | CTSS (0.44) | CTSSCTSKKDM4DGPR139KCNA5 | |
| SCHEMBL28508296 | 0.85 | GRIA1 (0.47) | CTSSCTSKCTSBCTSL | |
| SCHEMBL31156795 | 0.81 | AAK1 (0.44) | CTSSCTSK | |
| SCHEMBL25811680 | 0.81 | AAK1 (0.44) | CTSSCTSK | |
| SCHEMBL31156775 | 0.81 | AAK1 (0.44) | CTSSCTSK | |
| SCHEMBL16204368 | 0.81 | CTSL (0.47) | CTSSCTSKCTSL | |
| SCHEMBL3063248 | 0.81 | AAK1 (0.44) | CTSSCTSK | |
| SCHEMBL31156788 | 0.81 | AAK1 (0.44) | CTSSCTSK | |
| SCHEMBL25811681 | 0.81 | AAK1 (0.44) | CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716150-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005070932-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-08-04 | — | — | WO | disclosed |