Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141200 | 0.86 | CTSS (0.48) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL2141206 | 0.86 | CTSS (0.48) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL3626929 | 0.85 | SLC7A5 (0.54) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL6046349 | 0.85 | SLC7A5 (0.54) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL13807452 | 0.85 | SLC7A5 (0.54) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL3621416 | 0.84 | CTSS (0.49) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL4276615 | 0.84 | CTSS (0.49) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL31407583 | 0.84 | CACNA1B (0.52) | CTSSCTSKCTSBCTSLBCHE | |
| SCHEMBL23900516 | 0.83 | JAK2 (0.50) | KLK5CTSSCTSKCTSBCTSL | |
| SCHEMBL21799327 | 0.82 | CTSL (0.64) | KLK5CTSSCTSKCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716150-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005070932-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-08-04 | — | — | WO | disclosed |