Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | MMP9 | P14780 | 1/20 | 0.62 |
| ▸ | AANAT | Q16613 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL176108 | 0.86 | IDO1 (0.70) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL627038 | 0.85 | MEN1 (0.74) | MEN1KMT2ALMNACYP1A2PKM | |
| SCHEMBL2799585 | 0.85 | MEN1 (0.65) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL14700058 | 0.85 | IDO1 (0.68) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL6029287 | 0.84 | MAPT (0.67) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL5625480 | 0.82 | IDO1 (0.69) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL6703001 | 0.82 | MMP9 (0.75) | MEN1KMT2ALMNACYP1A2PKM | |
| SCHEMBL1520003 | 0.81 | IDO1 (0.76) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL6028502 | 0.81 | SPR (0.67) | IDO1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL29507373 | 0.81 | IDO1 (0.67) | IDO1MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709040-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | Sirenade Pharmaceuticals AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068458-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | SIRENADE PHARMACEUTICALS AG (DE) | 2005-07-28 | — | — | WO | disclosed |
| EP-1555264-A1 | Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase. | Sireen AG (DE) | 2005-07-20 | — | — | EP | disclosed |