SCHEMBL6028657

SCHEMBL6028657

O=C(Cc1ccc2ccccc2c1)C1=C(O)C(CCc2ccccc2)=NC1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.45
CYP1A2 P05177 1/20 0.41
SOX18 P35713 1/20 0.41
SIGMAR1 Q99720 2/20 0.39
NR1H4 Q96RI1 1/20 0.39
AKR1B1 P15121 1/20 0.39
FFAR1 O14842 1/20 0.38
NLRP3 Q96P20 1/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA3 P07451 1/20 0.37
CA4 P22748 1/20 0.37
CA5A P35218 1/20 0.37
CA7 P43166 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37
DAO P14920 1/20 0.37
PLAU P00749 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6029060 0.78 TDP1 (0.50)
SCHEMBL6028438 0.77 NPC1 (0.54) ALOX5FFAR1MEN1KMT2A
SCHEMBL6028495 0.76 LMNA (0.38) FFAR1DAO
SCHEMBL6028363 0.74 TP53 (0.43) DAO
SCHEMBL6028905 0.72 KDM4E (0.44) MEN1KMT2A
SCHEMBL4666706 0.71 ALOX5 (0.43) ALOX5CYP1A2SOX18SIGMAR1NR1H4
SCHEMBL4666877 0.71 ALOX5 (0.43) ALOX5CYP1A2SOX18SIGMAR1NR1H4
SCHEMBL6028324 0.70 SCN1A (0.36) FFAR1DAO
SCHEMBL6028310 0.70 ABCB1 (0.44) ALOX5
SCHEMBL16863710 0.69 ALOX5 (0.58) ALOX5CYP1A2NR1H4AKR1B1NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1689729-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. Hoffmann-La Roche AG (CH) 2006-08-16 EP claimed
WO-2005058857-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. HOFFMANN-LA ROCHE AG (CH) 2005-06-30 WO claimed
EP-1689729-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. Hoffmann-La Roche AG (CH) 2006-08-16 EP disclosed
WO-2005058857-A1 TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE F. HOFFMANN-LA ROCHE AG (CH) 2005-06-30 WO disclosed