Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.60 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL28123010 | 0.79 | PRKCA (0.86) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| 1,2-Dipalmitin SCHEMBL23319286 | 0.79 | PRKCA (0.86) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| 1,2-Dipalmitin SCHEMBL23319287 | 0.79 | PRKCA (0.86) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| Histamine SCHEMBL6014525 | 0.78 | MAPK1 (0.36) | PRKCAPRKCEPRKCQPRKCDLMNA | |
| SCHEMBL4176661 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| SCHEMBL23992003 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| SCHEMBL23668326 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| SCHEMBL16431424 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| SCHEMBL10426858 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 | |
| SCHEMBL7061646 | 0.78 | PRKCA (1.00) | PRKCAPRKCEPRKCQPRKCDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706149-A2 | LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS | ALZA CORPORATION (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20050191344-A1 | Liposome composition for delivery of therapeutic agents | ALZA CORPORATION | 2005-09-01 | — | — | US | disclosed |
| WO-2005070466-A2 | LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS | ALZA CORPORATION (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050191344-A1 | Liposome composition for delivery of therapeutic agents | PHOSPHO1, LIPA, SGMS1 | PRKCA 2434/4885PRKCE 3174/4885PRKCQ 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.