Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6029754 | 0.96 | DHODH (0.50) | DHODHPARP1ACVR1JAK2TGFBR1 | |
| SCHEMBL6029661 | 0.84 | PARP1 (0.46) | DHODHPARP1JAK2PIM1PIM3 | |
| SCHEMBL5074236 | 0.83 | CHRNB2 (0.43) | CHRNB2CHRNA4ATRPARP1ACVR1 | |
| SCHEMBL6029470 | 0.81 | DHODH (0.46) | DHODHPARP1ACVR1TGFBR1HDAC11 | |
| SCHEMBL6029678 | 0.81 | AURKA (0.50) | DHODHPARP1JAK2HDAC11 | |
| SCHEMBL3582373 | 0.80 | PARP1 (0.49) | CHRNB2CHRNA4ATRPARP1ACVR1 | |
| SCHEMBL6028570 | 0.79 | JAK2 (0.49) | DHODHPARP1JAK2 | |
| SCHEMBL6028789 | 0.79 | AURKA (0.55) | DHODHPARP1 | |
| SCHEMBL6028897 | 0.79 | AURKA (0.60) | DHODHPARP1 | |
| SCHEMBL6028613 | 0.78 | JAK2 (0.51) | DHODHPARP1JAK2HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | DHODH 674/4885CHRNB2 4171/4885CHRNA4 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.