Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.88 |
| ▸ | GAA | P10253 | 13/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.88 |
| ▸ | HPGD | P15428 | 10/20 | 0.88 |
| ▸ | CASP1 | P29466 | 9/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.84 |
| ▸ | CASP7 | P55210 | 8/20 | 0.84 |
| ▸ | GLA | P06280 | 5/20 | 0.84 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320682 | 0.92 | KDM4E (1.00) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL3320895 | 0.90 | KDM4E (0.81) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL20657021 | 0.88 | KDM4E (0.77) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL6028874 | 0.86 | GAA (0.67) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL5810136 | 0.86 | KDM4E (0.74) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL5823844 | 0.86 | KDM4E (0.66) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL3325553 | 0.85 | ALDH1A1 (1.00) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL5812956 | 0.85 | KDM4E (0.68) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL5809487 | 0.85 | KDM4E (0.68) | KDM4EGAAALDH1A1HPGDCASP1 | |
| SCHEMBL6029380 | 0.85 | KDM4E (0.68) | KDM4EGAAALDH1A1HPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SLC5A2, SLC5A1, QDPR | KDM4E 2337/4885GAA 230/4885ALDH1A1 416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.