Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.40 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.40 |
| ▸ | RPS17 | P08708 | 1/20 | 0.40 |
| ▸ | RPSA | P08865 | 1/20 | 0.40 |
| ▸ | RPS2 | P15880 | 1/20 | 0.40 |
| ▸ | RPL35A | P18077 | 1/20 | 0.40 |
| ▸ | RPL7 | P18124 | 1/20 | 0.40 |
| ▸ | RPL17 | P18621 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6030077 | 0.88 | MEN1 (0.52) | MEN1KMT2ASUV39H2ACP1 | |
| SCHEMBL6029070 | 0.85 | JAK2 (0.47) | JAK2JAK1JAK3PDPK1RPS6KB1 | |
| SCHEMBL6030368 | 0.84 | JAK2 (0.45) | JAK2JAK1JAK3PDPK1RPS6KB1 | |
| SCHEMBL7831160 | 0.79 | EP300 (0.46) | JAK2JAK1JAK3MEN1KMT2A | |
| SCHEMBL7849609 | 0.78 | EP300 (0.45) | JAK2JAK1JAK3MEN1KMT2A | |
| SCHEMBL8180795 | 0.78 | EP300 (0.45) | JAK2JAK1JAK3MEN1KMT2A | |
| SCHEMBL6028846 | 0.74 | AKT1 (0.40) | JAK2JAK1JAK3PDPK1RPS6KB1 | |
| SCHEMBL6028841 | 0.74 | POLB (0.49) | MEN1KMT2ACHEK2 | |
| SCHEMBL6029198 | 0.74 | HPGD (0.48) | MEN1KMT2ASUV39H2ACP1 | |
| SCHEMBL6030277 | 0.73 | L3MBTL1 (0.53) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |
| EP-1521582-A1 | 2,5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-04-13 | — | — | EP | disclosed |
| US-20040014775-A1 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC | 2004-01-22 | — | — | US | disclosed |
| WO-2004004731-A1 | 2, 5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS IX | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014775-A1 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | CCR3, CCR1, CCRL2 | JAK2 738/4885JAK1 2756/4885JAK3 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.