Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 5/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028762 | 0.83 | BTK (0.47) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL6028881 | 0.81 | PLK4 (0.45) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL6028712 | 0.80 | DHODH (0.46) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL1654110 | 0.79 | KDM4E (0.52) | CDC7KDM4EALDH1A1NPC1LMNA | |
| SCHEMBL5074121 | 0.78 | PARP1 (0.53) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL5478847 | 0.78 | KDM4E (0.55) | PARP1KDM4EALDH1A1NPC1LMNA | |
| SCHEMBL6028761 | 0.78 | CDC7 (0.49) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL6029520 | 0.78 | CDC7 (0.62) | CDC7BTKDHODHCCNA2CDK2 | |
| SCHEMBL4342616 | 0.77 | CDC7 (0.61) | CDC7BTKDHODHPARP1KDM4E | |
| SCHEMBL6029569 | 0.77 | DHODH (0.51) | BTKDHODHPARP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | CDC7 1138/4885BTK 3015/4885DHODH 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.