Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663283 | 0.75 | FFAR1 (0.46) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL4663289 | 0.75 | FFAR1 (0.46) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL4663286 | 0.75 | FFAR1 (0.46) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL4663056 | 0.74 | FFAR1 (0.46) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL659105 | 0.73 | SLC7A5 (0.69) | FFAR1FFAR4LTA4HLAP3PPARG | |
| SCHEMBL515522 | 0.73 | SLC7A5 (0.69) | FFAR1FFAR4LTA4HLAP3PPARG | |
| SCHEMBL288912 | 0.73 | SLC7A5 (0.69) | FFAR1FFAR4LTA4HLAP3PPARG | |
| SCHEMBL17738622 | 0.72 | LTA4H (0.64) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL14559932 | 0.72 | LTA4H (0.64) | FFAR1FFAR4LTA4HLAP3LNPEP | |
| SCHEMBL2603686 | 0.72 | LTA4H (0.64) | FFAR1FFAR4LTA4HLAP3LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | claimed |
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | claimed |
| EP-1689729-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. Hoffmann-La Roche AG (CH) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005058857-A1 | TETRONIC AND TETRAMIC ACIDS AS INHIBITORS OF BETA-SECREASE | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |