Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028518 | 0.94 | CHEK1 (0.39) | CHEK1LMNAPOLBATMMAPT | |
| SCHEMBL6028227 | 0.94 | LMNA (0.41) | LMNAPOLBATMMAPTRAB9A | |
| SCHEMBL6030459 | 0.94 | LMNA (0.41) | CHEK1LMNAPOLBATMMAPT | |
| SCHEMBL6029095 | 0.91 | CHEK1 (0.39) | CHEK1LMNAPOLBMAPTRAB9A | |
| SCHEMBL6029378 | 0.90 | LMNA (0.40) | CHEK1LMNAPOLBATMMAPT | |
| SCHEMBL6028843 | 0.90 | LMNA (0.38) | LMNAPOLBATMMAPTRAB9A | |
| SCHEMBL6029156 | 0.88 | LMNA (0.41) | LMNAPOLBATMMAPTRAB9A | |
| SCHEMBL6029808 | 0.88 | LMNA (0.41) | CHEK1LMNAPOLBATMMAPT | |
| SCHEMBL6029268 | 0.88 | MAPT (0.43) | LMNAPOLBATMMAPTRAB9A | |
| SCHEMBL6029102 | 0.88 | CHEK1 (0.39) | CHEK1LMNACCNT1GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |